Over the last years, the e-shop business has been booming in the Czech Republic. The year 2015 brought record sales to majority of the e-shop businesses and the expectations for 2016 are even higher. Influenced by this trend a number of Czech as well as foreign companies are considering their entrance on the scene of the e-shop business. To be successful, many factors must be observed and constantly improved. The key drivers from the business perspective are high quality goods, customer service, technologies and marketing. But there are also legal and tax aspects that shall be observed and set up in a right way.